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SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
USERS' SCORE
Excellent
Based on 151 Reviews
9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
9
Nattokinase shows strong clot-busting activity
Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM.
High relevance for cardiovascular treatment
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
9
Nattokinase enhances thrombin interaction
Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase.
Direct investigation of nattokinase
We explored the fascinating impact of nattokinase, a natural enzyme known for its blood-thinning properties, particularly its effect on blood clots. In our investigation, we examined how nattokinase interacts with thrombin, a key protein involved in the clotting process, and identified this enzyme as a significant substrate for nattokinase.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
Read More
9
G8 shows strong fibrinolytic activity
Fibrinolytic characteristics of G8 isolated from natto.
Direct focus on nattokinase effects
We aimed to explore how nattokinase, a key enzyme in natto—a traditional Japanese fermented soy product—affects blood clots. Our focus was on a newly isolated strain from Indonesian natto, named G8, which showed promising fibrinolytic activity, meaning its ability to dissolve blood clots.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
Read More
Most Useful Reviews
10
Eliminated headache
I highly recommend it! The swelling has gone down, and my blood is flowing well. I began taking it during the pandemic and since then, I've not had a headache, which is remarkable for me.
Read More
9.5
Blood clot prevention
Nattokinase is derived from fermented soybeans. It has a broad range of benefits, including heart health and reducing blood clots. I recommend it during the pandemic to reduce blood clot risks. This is not medical advice.
Read More
10
Supports circulatory system
Nattokinase helps dilute blood and dissolve blood clots. It's an enzyme that promotes a healthy circulatory system and lowers the risk of coronary heart disease and stroke. The quality is excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
9
Nattokinase shows promise for blood clots
A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation.
Highly relevant investigation of nattokinase
We explored the impact of nattokinase, a natural enzyme known for breaking down blood clots, particularly in the context of acute myocardial infarction (MI), a serious heart condition often caused by these clots. The study investigated a special formulation combining nattokinase with a manganese oxide nanozyme, designed to enhance its effectiveness and stability.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Read More
9
Nattokinase's efficacy enhanced via nanorobots
Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis.
Significant thrombolytic effect observed
We explored the effectiveness of a novel treatment combining nattokinase with magnetic vortex nanorobots for tackling blood clots. The study cleverly used these tiny robots, which are about 70 nanometers in size, powered by dual-frequency magnetic fields to improve drug delivery and enhance the effects of nattokinase.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
Read More
9
Cancer treatment and clot management
Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis.
Relevant combination therapy findings
We explored how a combination of nattokinase (NK) and heparin (HP) can tackle cancer-related thrombosis (CAT), a common issue in cancer patients that can worsen their condition and quality of life. In our approach, we developed an electrostatic complex of these two agents to mitigate the toxicity typically associated with intravenous NK administration.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
Read More
9
Nattokinase aids blood clot dissolution
ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug delivery systems for the treatment of inflammatory and thrombotic complications.
Combination complicates isolated effect
We explored the effectiveness of nattokinase in helping dissolve blood clots while also addressing inflammation. The study successfully created amphiphilic block polymer-based nanovesicles that release both the anti-inflammatory drug indomethacin and nattokinase specifically at sites where reactive oxygen species (ROS) are plentiful—like inflamed or thrombotic tissues.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
Read More
9
Nattokinase shows strong clot-busting activity
Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM.
High relevance for cardiovascular treatment
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 151 Reviews
9
10
Eliminated headache
I highly recommend it! The swelling has gone down, and my blood is flowing well. I began taking it during the pandemic and since then, I've not had a headache, which is remarkable for me.
10
Supports circulatory system
Nattokinase helps dilute blood and dissolve blood clots. It's an enzyme that promotes a healthy circulatory system and lowers the risk of coronary heart disease and stroke. The quality is excellent.
10
Improves circulation
Nattokinase, a soy-derived enzyme, dissolves fibrin in blood vessels and lowers cholesterol levels, thus promoting heart health. I have been taking it for four months without any issues.
10
Effective treatment
I take nattokinase on my doctor's advice due to blood vessel issues. Following its use, I have seen no signs of atherosclerosis or blood clots, and my tests confirm everything is fine.
10
Restored normal blood
It worked great for me! My platelet levels were high, and after taking it twice daily for three months, everything returned to normal. I’m very satisfied with this product.
